解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Recently, TWIST, a basic helix-loop-helix transcription factor, is suggested to be an oncogene because of its over-expression in many types of human cancer and its positive role in promoting cell survival. The aim of this study was to investigate the role of TWIST on the growth of human epithelial cells. Using two imm...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm185
更新日期:2007-12-01 00:00:00
abstract::Alternative pre-messenger RNA (mRNA) splicing is a key molecular event that allows for protein diversity and plays important roles in development and disease. Alternative pre-mRNA splicing regulations during spermatogenesis and alternative pre-mRNA splicing etiology in testicular tumorigenesis are yet to be characteri...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm194
更新日期:2007-12-01 00:00:00
abstract::A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm210
更新日期:2007-12-01 00:00:00
abstract::N2-ethylidene-2'-deoxyguanosine (N2-ethylidene-dG) is a major DNA adduct induced by acetaldehyde. Although it is unstable in the nucleoside form, it is relatively stable when present in DNA. In this study, we analyzed three acetaldehyde-derived DNA adducts, N2-ethylidene-dG, N2-ethyl-2'-deoxyguanosine (N2-Et-dG) and a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm057
更新日期:2007-11-01 00:00:00
abstract::Telomerase contributes to the infinite replicative potential of cancer cells by conferring proliferation and survival through the regulation of growth factors and apoptotic proteins. Although it is generally known that the phytoestrogen, genistein, has telomerase-repressing and anti-proliferative effects on various ca...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm148
更新日期:2007-11-01 00:00:00
abstract::Apurinic/apyrimidinic endonuclease/redox effector factor-1 (APE/Ref-1) is a multifunctional protein involved both in DNA base excision repair and redox regulation. Studies have suggested that abnormal Ref-1 levels and/or activities are associated with tumor progression and sensitivities to treatment, but no direct evi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm128
更新日期:2007-11-01 00:00:00
abstract::The natural flavonoid quercetin has been suggested by epidemiological studies to have preventive activity against lung cancer; however, the mechanism of which has not been well elucidated. In this report, we demonstrate that quercetin significantly enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAI...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm133
更新日期:2007-10-01 00:00:00
abstract::The expression of cyclooxygenase-2 (COX-2) has been reported as an indicator of poor prognosis in a wide variety of human tumors, including colon, breast and uveal melanoma (UM). COX-2 inhibitors have shown promise in controlling the malignancy of several types of tumors. Previous studies have demonstrated the efficac...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm091
更新日期:2007-09-01 00:00:00
abstract::The P53 tumor suppressor pathway plays an important role in cancer development. The auto-regulatory feedback mechanism of the P53 and MDM2 expression is critical in keeping proper tumor suppressor function of this pathway. This study examined the effect of P53 Arg72Pro variants on transactivation of polymorphic MDM2 p...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm168
更新日期:2007-09-01 00:00:00
abstract::The Wnt-beta-catenin pathway plays a central role in colorectal tumorigenesis. Frizzled-related protein (FRZB, also termed secreted frizzled-related protein 3, sFRP3) antagonizes the signaling of wingless (Wnt) ligands through the frizzled membrane-bound receptors, resulting in beta-catenin destabilization thereby sup...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm077
更新日期:2007-09-01 00:00:00
abstract::Isothiocyanates are anticarcinogenic phytochemicals found in cruciferous vegetables that both induce and are substrates for the gluthatione S-transferases (GSTs). The GSTs are phase II metabolizing enzymes involved in metabolism of various bioactive compounds. Functional polymorphisms in GST genes have been identified...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm141
更新日期:2007-09-01 00:00:00
abstract::Aloe-emodin (AE), one of the main bioactive anthraquinones of Rheum palmatum, possesses potent antitumor properties. Our previous proteomic study revealed that AE-induced apoptosis was associated with oxidative stress and oxidation of many redox-sensitive proteins. In this study, we aimed to further dissect the cell d...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm143
更新日期:2007-09-01 00:00:00
abstract::Consumption of fruits and vegetables has been associated with a decrease in cancer incidence and cardiovascular disease, presumably caused by antioxidants. We designed a human intervention study to assess antioxidative and possible anti-genotoxic properties of fruit-borne antioxidants. We hypothesized that individuals...
journal_title:Carcinogenesis
pub_type: 杂志文章,随机对照试验
doi:10.1093/carcin/bgm145
更新日期:2007-08-01 00:00:00
abstract::Tumor suppression by insulin-like growth factor-binding protein-3 (IGFBP-3) has been demonstrated to occur via insulin-like growth factor-dependent and -independent mechanisms in vitro and in vivo. We have recently described IGFBP-3-induced mitochondrial translocation of the nuclear receptors RXRalpha/Nur77 in the ind...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm088
更新日期:2007-08-01 00:00:00
abstract::Cyclin D1 is one of the major enhancers of cell cycle progression and its expression is regulated in several growth stimulatory signaling pathways. ARA54 is an androgen receptor (AR) co-activator that enhances AR-dependent transcriptional activation. Although expression of ARA54 mRNA is observed in a variety of human ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm120
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Variations in genetic mutations in pancreatic carcinoma between different geographical regions have not been studied extensively, especially in developing countries where pancreatic cancer is relatively rare. METHODS:We studied the molecular pathology of 54 pancreatic adenocarcinomas from Egyptian patients ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm138
更新日期:2007-08-01 00:00:00
abstract::Mice with non-phosphorylated serine 389 in p53 are susceptible for bladder tumors induced by 2-acetylaminofluorene (2-AAF). Since p53 is a transcription factor, this might well be preceded by differences in the regulation of gene expression. Microarray analysis was used to determine early transcriptional changes that ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm041
更新日期:2007-08-01 00:00:00
abstract::Many chemoradiation therapies cause DNA damage through oxidative stress. An important cellular mechanism that protects cells against oxidative stress involves DNA repair. One of the primary DNA repair mechanisms for oxidative DNA damage is base excision repair (BER). BER involves the tightly coordinated function of fo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm072
更新日期:2007-08-01 00:00:00
abstract::Colorectal cancer is the second leading cause of cancer deaths worldwide with diet playing a prominent role in disease initiation and progression. Flavonoids are secondary plant compounds that are suggested as protective ingredients of a diet rich in fruits and vegetables. We here tested whether flavone, a flavonoid t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm040
更新日期:2007-07-01 00:00:00
abstract::Animal studies demonstrated that females are more susceptible than males to benzo[a]pyrene (BaP)-induced toxicities, including lung carcinogenesis. Elevation of cyclooxygenase-2 (COX-2) expression has been shown to increase the risk of cancer development. BaP induces COX-2 expression, and an interaction between BaP an...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm013
更新日期:2007-07-01 00:00:00
abstract::The nicotine-derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces lung adenocarcinoma through formation of DNA adducts. Our previous research on susceptibility to tobacco-induced carcinogenesis focused on benzo[a]pyrene diol epoxide (BPDE) as the in vitro mutagen for phenotype measurements ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm029
更新日期:2007-07-01 00:00:00
abstract::Cells from patients with genomic instability syndromes have high predisposition to cancer. However, little is known about whether these mutant cells have high susceptibility to oncogenic transformation. We have tested the hypothesis that a defect in maintaining genome integrity is necessary but not sufficient alone fo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm025
更新日期:2007-06-01 00:00:00
abstract::DNA polymerase beta (polbeta) is a major contributor to mammalian DNA damage repair through its gap-filling DNA synthesis and 5'-deoxyribose phosphate lyase activities. In this way, polbeta plays pivotal roles in the repair of oxidative DNA damage, replication, embryonic survival, neuronal development, meiosis, apopto...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl239
更新日期:2007-06-01 00:00:00
abstract::Xanthorrhizol is an active component isolated from Curcuma xanthorrhiza Roxb. (Zingiberaceae) that is traditionally used in Indonesia for medicinal purposes. In the present study, we found that the topical application of xanthorrhizol before 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment significantly inhibits T...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm005
更新日期:2007-06-01 00:00:00
abstract::The caspase proteins are essential for the regulation of normal B cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl196
更新日期:2007-04-01 00:00:00
abstract::Aberrant crypt foci (ACF) are microscopic surface abnormalities that are putative precursors to colorectal cancer (CRC). ACF exhibit similar histological and molecular abnormalities to adenomas and CRC and potentially represent useful biomarkers of cancer risk. Microsatellite instability (MSI) is one molecular abnorma...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl209
更新日期:2007-04-01 00:00:00
abstract::Breast cancer incidence is increased in women with both high and low birth weight. The latter is also associated with hyperglycaemia, insulin resistance and type-2 diabetes, each of which independently increases breast cancer risk. We showed previously in our model of poor early-growth that pregnancy estradiol levels ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl166
更新日期:2007-03-01 00:00:00
abstract::Mutations in genes important for the preservation of genome stability can increase the frequency of gene amplification, a process relevant to tumor development. To investigate whether telomerase, the enzyme deputed to telomere maintenance, also plays a role in gene amplification, we studied the amplification of the ca...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl158
更新日期:2007-03-01 00:00:00
abstract::Insulin-like growth factor 1 receptor (IGF-1R) activation is required for prostate cell proliferation. Prostate cancer is one of the most commonly diagnosed malignant tumors in Western countries. Overexpression of IGF-1R in prostate cancer is associated with tumor growth. These suggest that IGF-1R inhibitory agents ma...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl189
更新日期:2007-03-01 00:00:00
abstract::CXCR4 is a chemokine receptor probably involved in the homing of metastatic breast cancer, and its expression is modulated by tumor environmental stimuli such as hepatocyte growth factor (HGF) and hypoxia. Here, we demonstrate that, depending on the stimulus, different transcription factors can cooperate in enhancing ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl129
更新日期:2007-02-01 00:00:00
abstract::Folate and vitamin D have been shown to be influenced by ultraviolet (UV) radiation. UVA radiation can break down plasma folate, whereas vitamin D can be synthesized in UVB-exposed skin. Folate metabolism is involved in DNA synthesis and repair, and vitamin D processes anti-proliferative effects. The functions of both...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl156
更新日期:2007-02-01 00:00:00
abstract::Apoptosis, a form of programmed cell death, plays a fundamental role in the maintenance of tissues and organ systems by providing a controlled cell deletion to balanced cell proliferation. The last decade has witnessed an exponential increase in the number of studies investigating how different components of the diet ...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgl243
更新日期:2007-02-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) are important regulators of angiogenesis. HIF-1 is composed of HIF-1alpha and HIF-1beta subunits, and regulates VEGF expression at transcriptional level. In this study, we demonstrated that insulin induced H2O2 production and p70S6K1 acti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl085
更新日期:2007-01-01 00:00:00
abstract::Ovarian cancer is developed from a single layer of thin epithelial cells covering the surface of ovary, named human ovarian surface epithelial cells. Like all primary human cells, human ovarian surface epithelial cells have a finite life span and will go into senescence and eventually die when cultured in vitro. Immor...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl115
更新日期:2007-01-01 00:00:00
abstract::The transcription factor Sp1 has been implicated in cell-type-specific activation of transforming growth factor-beta (TGFbeta) target genes in normal epithelial cells as well as in aberrant gene activation by TGFbeta in epithelial tumor cells. Here, we have examined the interaction of Sp1 with components of the Smad s...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl078
更新日期:2006-12-01 00:00:00
abstract::Angiogenesis, the formation of new blood vessels, is critical to tumor growth and metastasis. Vascular endothelial growth factor (VEGF), an important angiogenic activator, is essential for angiogenesis. Our laboratory has used a rodent model of human esophageal squamous cell carcinoma (ESCC) to identify putative chemo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl109
更新日期:2006-11-01 00:00:00
abstract::The fetus and neonate are sensitive targets for chemically induced carcinogenesis. Few studies have examined the risk/benefit of chemoprotective phytochemicals, given in the maternal diet, against transplacental carcinogenesis. In this study, B6129 SF1/J (AHR(b-1/d)) and 129Sv/ImJ (AHR(d/d)) mice were cross-bred. The ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl072
更新日期:2006-10-01 00:00:00
abstract::The MDM2 protein negatively regulates p53 expression level in modulating DNA repair, cell-cycle control, cell growth and apoptosis. Polymorphisms in the promoter region of the MDM2 gene have been shown to alter protein expression and may, thus, play a role in carcinogenesis. To test our hypothesis that the MDM2 promot...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl047
更新日期:2006-10-01 00:00:00
abstract::Peroxisome proliferator-activated receptor (PPAR) gamma is a ligand-activated nuclear receptor that plays a key role in adipogenesis and adipocyte gene expression, and has recently been linked with possible antineoplastic effects in colonic carcinogenesis. PPARgamma2 and gamma3 are two transcripts arising from the PPA...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl001
更新日期:2006-09-01 00:00:00
abstract::The tumor suppressor PTEN antagonizes phosphatidylinositol 3-kinase (PI3K), which contributes to tumorigenesis in many cancer types. While PTEN mutations occur in some melanomas, their precise mechanistic consequences have yet to be elucidated. We sought to identify novel downstream effectors of PI3K using a combinati...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl016
更新日期:2006-09-01 00:00:00